About

I’m a computational scientist with a Ph.D. in Chemical and Biochemical Engineering, specializing in the intersection of molecular biology, machine learning, and rigorous statistical analysis.

My current work focuses on antibody developability assessment—identifying post-translational modification liabilities (particularly glycosylation risks) that AI-driven protein design tools often miss. I bridge the gap between computationally designed biologics and manufacturing reality.

Technical Focus

  • Molecular Simulations: AMBER, molecular dynamics, protein structure analysis
  • Machine Learning: PyTorch, scikit-learn, CNN-LSTM architectures for binding prediction
  • Bayesian Statistics: Probabilistic modeling, uncertainty quantification
  • Cloud Infrastructure: AWS, Docker, Kubernetes

Background

Over 10 years of experience applying computational methods to biological problems, including:

  • Antibody glycoform heterogeneity modeling
  • RNA-seq analysis and liver transcriptomics
  • Clinical trial data analysis
  • Large-scale trajectory data processing (100+ TB)

I value scientific rigor, reproducibility, and the ability to communicate complex findings clearly.


Connect

📧 clgaughan@proton.me
🔗 LinkedIn
💻 GitHub